Ptk2 CLIA Kit for Rat(Rattus norvegicus) | EIAab.comPtk2 CLIA Kit for Rat(Rattus norvegicus)

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Ptk2 (Gene name),

Focal adhesion kinase 1 (Protein name ), FAK1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ptk2(Fak;Fak1);

Protein name:

Focal adhesion kinase 1(FADK 1);

Alternative:

pp125FAK;Protein-tyrosine kinase 2(FRNK);pp125FAK;p125FAK;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with CAS family members. Interacts with GIT1. Interacts with SORBS1. Interacts with BCAR3. Interacts with SHB. Interacts with PXN. Component of a complex that contains at least FER, CTTN and PTK2/FAK. Interacts with BMX. Interacts with STEAP4. Interacts with ZFYVE21. Interacts with ESR1. Interacts with PIK3R1 or PIK3R2. Interacts with SRC. Interacts with EPHA2 (inactive form); participates to EPHA2 downstream signaling. Interacts with CD4; this interaction requires the presence of HIV-1 gp120. Interacts with EPHA1 (kinase activity-dependent) (By similarity). Interacts with RGNEF. Interacts with TGFB1I1.

Function:

Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly (By similarity). Plays a potential role in oncogenic transformations resulting in increased kinase activity.

Subcellular Location:

Cell junction focal adhesion Cell membrane Peripheral membrane protein Cytoplasmic side Constituent of focal adhesions.

Protein Attributes:

Sequence length:

1055

Sequence:

50:

100:

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350:

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450:

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600:

650:

700:

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950:

1000:

1050:

1055:

QTRPH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:25614

String:

O35346

SMR:

O35346

UniGene:

Rn.2809

Pfam:

PF00373

Uniprot:

O35346

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ELISA Kit for Rat FADK 1

Cat.:

E1178c

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Packing:

96T

ELISA Kit for Rat FADK 1

Cat.:

E1178h

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96T

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ELISA Kit for Rat FADK 1

Cat.:

E1178r

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96T

ELISA Kit for Rat FADK 1

Cat.:

E1178m

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96T

CLIA Kit for Rat FADK 1

Cat.:

U1178h

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Manual:

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96T

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CLIA Kit for Rat FADK 1

Cat.:

U1178c

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96T

CLIA Kit for Rat FADK 1

Cat.:

U1178r

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96T

CLIA Kit for Rat FADK 1

Cat.:

U1178m

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96T

Polyclonal Antibody for Rat FADK 1

Cat.:

P1178Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat FADK 1

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P1178Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat FADK 1

Cat.:

P1178Rb-h

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40ug/0.2ml

Monoclonal Antibody for Rat FADK 1

Protein for Rat FADK 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of focal adhesion kinase, pp125FAK, from rat brain reveals multiple transcripts with different patterns of expression."
Burgaya F. , Girault J.A.
Brain Res. Mol. Brain Res.37:63-73(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: Sprague-Dawley.
tissue: Corpus striatum.
2.

Sasaki T. , Nagura K. , Sasaki H.
Submitted (1995-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 350-528 (ISOFORM 1)
strain: Wistar.
3.

"Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions."
Matsuya M. , Sasaki H. , Aoto H. , Mitaka T. , Nagura K. , Ohba T. , Ishino M. , Takahashi S. , Suzuki R. , Sasaki T.
J. Biol. Chem.273:1003-1014(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TGFB1I1
4.

"Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium."
Yi X.P. , Wang X. , Gerdes A.M. , Li F.
Hypertension41:1317-1323(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-722 AND SER-913;CHARACTERIZATION OF ISOFORM 2
5.

"Direct interaction of focal adhesion kinase with p190RhoGEF."
Zhai J. , Lin H. , Nie Z. , Wu J. , Canete-Soler R. , Schlaepfer W.W. , Schlaepfer D.D.
J. Biol. Chem.278:24865-24873(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARHGEF28
6.

"PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation."
Kadare G. , Toutant M. , Formstecher E. , Corvol J.C. , Carnaud M. , Boutterin M.C. , Girault J.A.
J. Biol. Chem.278:47434-47440(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-152;MUTAGENESIS OF LYS-152;INTERACTION WITH PIAS1;AUTOPHOSPHORYLATION;PHOSPHORYLATION AT TYR-397;SUBCELLULAR LOCATION
7.

"Focal adhesion kinase in netrin-1 signaling."
Ren X.R. , Ming G.L. , Xie Y. , Hong Y. , Sun D.M. , Zhao Z.Q. , Feng Z. , Wang Q. , Shim S. , Chen Z.F. , Song H.J. , Mei L. , Xiong W.C.
Nat. Neurosci.7:1204-1212(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DCC
8.

"Nuclear compartmentalization of FAK and FRNK in cardiac myocytes."
Yi X.P. , Zhou J. , Huber L. , Qu J. , Wang X. , Gerdes A.M. , Li F.
Am. J. Physiol.290:H2509-H2515(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PHOSPHORYLATION;CHARACTERIZATION OF ISOFORM 2

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